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KMID : 0380620120440030274
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Korean Journal of Food Science and Technology
2012 Volume.44 No. 3 p.274 ~ p.279
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Dissolution Profile Analysis of Hydroxypropyl Methylcellulose-based Vitamin C Tablets
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Cha Ja-Hyun
Hong Jun-Kee
Lee Sung-Wan
Cha Jae-Uk
Ko Won-Hwa
Baek Hyon-Ho
Park Hyun-Jin
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Abstract
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The objective of this study was to develop oral matrix tablets for the sustained release of vitamin C. In this study hydroxypropyl methylcellulose (HPMC) has been utilized as an excipient, as it is one of the most widely used polymers, for use during long periods of time in formations. The vitamin C tablet formulation depends on the molecular weight and concentration of sustained-delivery in HPMC. Anti-oxidants have been added as a dissolution medium in order to prevent vitamin C degradation in water. The dissolution test was carried out in a distilled water medium, and the release model equation was applied to analyze the vitamin C release pattern. The results demonstrated that the release and lasting power of vitamin C tablets, containing HPMC, lasted for more than 12 h.
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KEYWORD
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Vitamin C, matrix tablet, sustained release, hydroxypropyl methylcellulose, HPMC
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